Kick off is at 17:30 on Saturday 10 December.
The match will take place at the King Power Stadium. Here’s all the info you need about the ground.
The defending Premier League champions are looking to turn round their dreadful recent form, while their visitors bid to put on the pressure at the top of the table.
Yes – the match will be televised on BT Sport in the UK. Here’s the schedule.
International viewers can see their options here.
Check out the official Premier League ticket hub.
Nicolas Otamendi, Fernandinho and Sergio Aguero are all suspended, but Yaya Toure may still find himself in the City side despite a drink-driving charge this week.
Raheem Sterling has recovered from the knock he suffered against Burnley two weeks ago.
Kasper Schmeichel has returned to training for Leicester following a hand injury.
Claudio Ranieri: "This part of the season is our key moment. The players aren’t satisfied, they want to play better and fight more but it’s important to fight together as a team. Our strength was this, if we made a dream last season it’s because we were together, not because we were a big team. With our effort we made a story. Do you see the same team from last season? I don’t see, we have to react, to come back."
Pep Guardiola: "In the long term, if you play good you are going to win. I want to feel. I am a coach for the results of course or I wouldn’t be here but I want to enjoy with my team. Sometimes it’s a little bit sad when you deserve to win but you are not able but it happens to all teams around the world. Always I am focused on the way you have to play, not the result. The result is a consequence of what you do. If we play like we did against Chelsea or Celtic, we are going to do good things. If we play like (in wins over) Crystal Palace or Burnley, we are not going to do absolutely anything."
Manchester City haven’t lost an away game to Leicester in the Premier League (D2 L3), with their last top-flight league defeat in Leicester coming in March 1987.
Claudio Ranieri has won seven of his eight Premier League games against Manchester City, with the only draw coming at the King Power Stadium last season.
Manchester City have won their last six fixtures against defending champions in the Premier League, last losing to Chelsea in March 2011.
Jamie Vardy has scored against 20 of the 23 different teams he’s faced in the Premier League, but Manchester City are one of the three opponents he’s yet to net against in the competition (4 apps, 0 goals), alongside Hull City & Middlesbrough.
Riyad Mahrez has created just one goalscoring chance for Jamie Vardy in the Premier League this season so far, despite them playing 939 mins together. Last season, the Algerian created 22 chances for him (with five of those being assists) in 2815 minutes together on the pitch – one every 128 minutes.
Robert Huth scored twice for Leicester in their 3-1 win over Manchester City last season, in what was their first league win over the Citizens since November 2003.
In the last five Premier League matches that Sergio Aguero hasn’t appeared in for Manchester City, Nigerian striker Kelechi Iheanacho has scored five goals.
Man City goalkeeper Claudio Bravo has been passed to on 245 occasions this season – more often than any other keeper in the Premier League.
Manchester City have won their last six league meetings with the reigning Premier League champions – winning home and away against Manchester United in 2011-12 and 2013-14 and against Chelsea in 2015-16.
This is Pep Guardiola’s lowest points tally after 14 games of a top-flight season as a manager (30); surpassing his 31-point tally after 14 games in charge of Barcelona’s 2011-12 La Liga campaign.
Manchester City have made the most changes to their starting XI overall this season in the Premier League (46). Whilst in charge of Bayern Munich, the German side made the second most last season (111), while they made more than any other side in both 2013-14 (120) and 2014-15 (106).
Leicester 17/4, Draw 16/5, Man City 8/11 (Best odds at the time of writing)